We Caring Human Health, Animal Health, & Environment Well Being
We will combat AMR together through implementing Global Action Plan (2016) of World Health Organization (WHO), National Action Program (2017) of Pakistan, and Antimicrobial Stewardship (AMS) Program. The collaborative approaches, awareness sessions, seminars, and walks for general and professional communities, provision of modern diagnostic tools, discussions with stakeholders and policy makers, and other approaches will be part of the forum that will help us in achieving our organization goals.
Antimicrobials especially Antibiotics play an important role in the treatment of plants and animal’s diseases that is directly or indirect linked with food security. The antimicrobials usage varies worldwide; the rates are higher in middle-income countries like Pakistan, India, and Bangladesh. Very few countries have a record of antimicrobial usage in agriculture. As the demand for animal-sourced food and food products has been increasing in previous decade, the antimicrobials demand is also expected to rise, unless practices are modified to minimize their need.
Antimicrobials especially Antibiotics play an important role in the treatment of plants and animal’s diseases that is directly or indirect linked with food security. The antimicrobials usage varies worldwide; the rates are higher in middle-income countries like Pakistan, India, and Bangladesh. Very few countries have a record of antimicrobial usage in agriculture. As the demand for animal-sourced food and food products has been increasing in previous decade, the antimicrobials demand is also expected to rise, unless practices are modified to minimize their need.
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The reason for AMR program is simple but the existing problems are much complex. Antimicrobial Resistance (AMR) is not a new challenge for the modern world and it was started with the discovery of Antimicrobials. Currently, it is one of the major causes of deaths in the world with more than 4.5 million deaths annually. In 2050, the fatality rate will be more than 10 million per year if AMR microbes remain uncontrolled. In the U.S., more than 2.8 million antimicrobial-resistant infections occur each year. In the European Union alone, infections caused by only a subset of all multi-drug resistant bacteria are responsible for around 25,000 deaths per year. More than 35,000 people die as a result, according to CDC’s 2019 Antibiotic Resistance (AR) Threats Report.
Nearly 2 million Americans per year develop hospital-acquired infections (HAIs), resulting in 99,000 deaths – the vast majority of which are due to antibacterial-resistant pathogens. Two common HAIs alone (sepsis and pneumonia) killed nearly 50,000 Americans and cost the U.S. health care system more than $8 billion in 2006. The worldwide loses will be $1 trillion in 2050 due to AMR microbes if not tackled.
Pakistan is also facing AMR related problems with higher resistance rates. There are more than15,000 Multidrug resistant (MDR) TB cases per years and it ranks 5th in TB burden countries. In Pakistan the prevalence of TB is at 4th Position in and it accounts 61% burden in East Mediterranean Region. Methicillin Resistant Staph Aureus (MRSA) found in 49% of S. aureus in Pakistan. In 2016, XDR Salmonella was 100% resistance to Fluoroquinolones. The resistance in E. coli to 3rd generation Cephalosporin's is 36.0% in different studies.
Lack of drug discoveries, lack of funding, low quality drugs productions, and high resistance in microbes are the key factors for AMR program. Currently, there are only 5% of antimicrobial agents in the pipeline and it will take 10 years to be in the market. The efficacy of miracle drugs is decreasing each day that will create problems in surgery, chemotherapy, organ transplantation and care of premature infants and there will be no treatment options available in 2050.